| Grundserie | Ma | +/- | P | |||||||
| 1 | Columbus Crew | 4 | 3 | 8 | 4 | 3 | 10 | 8 | 6 | 18 |
| 2 | Charlotte FC | 4 | 8 | 12 | 4 | -2 | 4 | 8 | 6 | 16 |
| 3 | FC Cincinnati | 4 | 4 | 10 | 4 | -3 | 6 | 8 | 1 | 16 |
| 4 | Inter Miami | 4 | 2 | 8 | 3 | 4 | 7 | 7 | 6 | 15 |
| 5 | Nashville | 5 | 5 | 10 | 3 | -1 | 3 | 8 | 4 | 13 |
| 6 | Philadelphia Union | 4 | 2 | 7 | 4 | 2 | 6 | 8 | 4 | 13 |
| 7 | Chicago Fire | 3 | 0 | 3 | 5 | 2 | 9 | 8 | 2 | 12 |
| 8 | New York Red Bulls | 4 | 4 | 10 | 4 | -2 | 2 | 8 | 2 | 12 |
| 9 | Orlando City | 4 | 3 | 7 | 4 | 0 | 5 | 8 | 3 | 12 |
| 10 | New York City FC | 4 | 2 | 9 | 4 | -2 | 2 | 8 | 0 | 11 |
| 11 | Atlanta United | 6 | 0 | 8 | 2 | -2 | 1 | 8 | -2 | 9 |
| 12 | New England Revolution | 3 | -2 | 3 | 4 | -1 | 4 | 7 | -3 | 7 |
| 13 | DC United | 5 | -1 | 5 | 3 | -8 | 1 | 8 | -9 | 6 |
| 14 | Toronto FC | 3 | -1 | 2 | 5 | -5 | 2 | 8 | -6 | 4 |
| 15 | CF Montréal | 1 | -1 | 0 | 7 | -8 | 2 | 8 | -9 | 2 |
| Grundserie | Ma | +/- | P | |||||||
| 1 | Columbus Crew | 4 | 3 | 8 | 4 | 3 | 10 | 8 | 6 | 18 |
| 2 | Charlotte FC | 4 | 8 | 12 | 4 | -2 | 4 | 8 | 6 | 16 |
| 3 | FC Cincinnati | 4 | 4 | 10 | 4 | -3 | 6 | 8 | 1 | 16 |
| 4 | Inter Miami | 4 | 2 | 8 | 3 | 4 | 7 | 7 | 6 | 15 |
| 5 | Nashville | 5 | 5 | 10 | 3 | -1 | 3 | 8 | 4 | 13 |
| 6 | Philadelphia Union | 4 | 2 | 7 | 4 | 2 | 6 | 8 | 4 | 13 |
| 7 | Chicago Fire | 3 | 0 | 3 | 5 | 2 | 9 | 8 | 2 | 12 |
| 8 | New York Red Bulls | 4 | 4 | 10 | 4 | -2 | 2 | 8 | 2 | 12 |
| 9 | Orlando City | 4 | 3 | 7 | 4 | 0 | 5 | 8 | 3 | 12 |
| 10 | New York City FC | 4 | 2 | 9 | 4 | -2 | 2 | 8 | 0 | 11 |
| 11 | Atlanta United | 6 | 0 | 8 | 2 | -2 | 1 | 8 | -2 | 9 |
| 12 | New England Revolution | 3 | -2 | 3 | 4 | -1 | 4 | 7 | -3 | 7 |
| 13 | DC United | 5 | -1 | 5 | 3 | -8 | 1 | 8 | -9 | 6 |
| 14 | Toronto FC | 3 | -1 | 2 | 5 | -5 | 2 | 8 | -6 | 4 |
| 15 | CF Montréal | 1 | -1 | 0 | 7 | -8 | 2 | 8 | -9 | 2 |
| Grundserie | Ma | +/- | P | |||||||
| 1 | Vancouver Whitecaps | 5 | 7 | 12 | 3 | 4 | 7 | 8 | 11 | 19 |
| 2 | Minnesota United | 3 | 3 | 7 | 5 | 1 | 8 | 8 | 4 | 15 |
| 3 | Colorado Rapids | 4 | 0 | 7 | 4 | 0 | 7 | 8 | 0 | 14 |
| 4 | Portland Timbers | 4 | 0 | 7 | 4 | 3 | 7 | 8 | 3 | 14 |
| 5 | San Diego FC | 4 | 4 | 8 | 4 | 2 | 6 | 8 | 6 | 14 |
| 6 | Austin FC | 4 | 1 | 7 | 4 | -3 | 6 | 8 | -2 | 13 |
| 7 | Los Angeles FC | 4 | 2 | 9 | 4 | -3 | 3 | 8 | -1 | 12 |
| 8 | FC Dallas | 4 | -3 | 3 | 4 | 2 | 8 | 8 | -1 | 11 |
| 9 | San Jose Earthquakes | 5 | 7 | 7 | 3 | -3 | 3 | 8 | 4 | 10 |
| 10 | Real Salt Lake | 4 | 1 | 6 | 4 | -6 | 3 | 8 | -5 | 9 |
| 11 | Seattle Sounders | 3 | 3 | 5 | 5 | -5 | 4 | 8 | -2 | 9 |
| 12 | St. Louis City | 4 | -1 | 4 | 4 | 0 | 4 | 8 | -1 | 8 |
| 13 | Houston Dynamo | 4 | -4 | 3 | 4 | -2 | 3 | 8 | -6 | 6 |
| 14 | Sporting Kansas City | 5 | -3 | 4 | 3 | -3 | 0 | 8 | -6 | 4 |
| 15 | Los Angeles Galaxy | 4 | -6 | 1 | 4 | -3 | 2 | 8 | -9 | 3 |
| Grundserie | Ma | +/- | P | |||||||
| 1 | Vancouver Whitecaps | 5 | 7 | 12 | 3 | 4 | 7 | 8 | 11 | 19 |
| 2 | Minnesota United | 3 | 3 | 7 | 5 | 1 | 8 | 8 | 4 | 15 |
| 3 | Colorado Rapids | 4 | 0 | 7 | 4 | 0 | 7 | 8 | 0 | 14 |
| 4 | Portland Timbers | 4 | 0 | 7 | 4 | 3 | 7 | 8 | 3 | 14 |
| 5 | San Diego FC | 4 | 4 | 8 | 4 | 2 | 6 | 8 | 6 | 14 |
| 6 | Austin FC | 4 | 1 | 7 | 4 | -3 | 6 | 8 | -2 | 13 |
| 7 | Los Angeles FC | 4 | 2 | 9 | 4 | -3 | 3 | 8 | -1 | 12 |
| 8 | FC Dallas | 4 | -3 | 3 | 4 | 2 | 8 | 8 | -1 | 11 |
| 9 | San Jose Earthquakes | 5 | 7 | 7 | 3 | -3 | 3 | 8 | 4 | 10 |
| 10 | Real Salt Lake | 4 | 1 | 6 | 4 | -6 | 3 | 8 | -5 | 9 |
| 11 | Seattle Sounders | 3 | 3 | 5 | 5 | -5 | 4 | 8 | -2 | 9 |
| 12 | St. Louis City | 4 | -1 | 4 | 4 | 0 | 4 | 8 | -1 | 8 |
| 13 | Houston Dynamo | 4 | -4 | 3 | 4 | -2 | 3 | 8 | -6 | 6 |
| 14 | Sporting Kansas City | 5 | -3 | 4 | 3 | -3 | 0 | 8 | -6 | 4 |
| 15 | Los Angeles Galaxy | 4 | -6 | 1 | 4 | -3 | 2 | 8 | -9 | 3 |
| Grundserie | Ma | +/- | P | |||||||
| 1 | Vancouver Whitecaps | 5 | 7 | 12 | 3 | 4 | 7 | 8 | 11 | 19 |
| 2 | Columbus Crew | 4 | 3 | 8 | 4 | 3 | 10 | 8 | 6 | 18 |
| 3 | Charlotte FC | 4 | 8 | 12 | 4 | -2 | 4 | 8 | 6 | 16 |
| 4 | FC Cincinnati | 4 | 4 | 10 | 4 | -3 | 6 | 8 | 1 | 16 |
| 5 | Inter Miami | 4 | 2 | 8 | 3 | 4 | 7 | 7 | 6 | 15 |
| 6 | Minnesota United | 3 | 3 | 7 | 5 | 1 | 8 | 8 | 4 | 15 |
| 7 | San Diego FC | 4 | 4 | 8 | 4 | 2 | 6 | 8 | 6 | 14 |
| 8 | Portland Timbers | 4 | 0 | 7 | 4 | 3 | 7 | 8 | 3 | 14 |
| 9 | Colorado Rapids | 4 | 0 | 7 | 4 | 0 | 7 | 8 | 0 | 14 |
| 10 | Philadelphia Union | 4 | 2 | 7 | 4 | 2 | 6 | 8 | 4 | 13 |
| 11 | Nashville | 5 | 5 | 10 | 3 | -1 | 3 | 8 | 4 | 13 |
| 12 | Austin FC | 4 | 1 | 7 | 4 | -3 | 6 | 8 | -2 | 13 |
| 13 | Orlando City | 4 | 3 | 7 | 4 | 0 | 5 | 8 | 3 | 12 |
| 14 | Chicago Fire | 3 | 0 | 3 | 5 | 2 | 9 | 8 | 2 | 12 |
| 15 | New York Red Bulls | 4 | 4 | 10 | 4 | -2 | 2 | 8 | 2 | 12 |
| 16 | Los Angeles FC | 4 | 2 | 9 | 4 | -3 | 3 | 8 | -1 | 12 |
| 17 | New York City FC | 4 | 2 | 9 | 4 | -2 | 2 | 8 | 0 | 11 |
| 18 | FC Dallas | 4 | -3 | 3 | 4 | 2 | 8 | 8 | -1 | 11 |
| 19 | San Jose Earthquakes | 5 | 7 | 7 | 3 | -3 | 3 | 8 | 4 | 10 |
| 20 | Atlanta United | 6 | 0 | 8 | 2 | -2 | 1 | 8 | -2 | 9 |
| 21 | Seattle Sounders | 3 | 3 | 5 | 5 | -5 | 4 | 8 | -2 | 9 |
| 22 | Real Salt Lake | 4 | 1 | 6 | 4 | -6 | 3 | 8 | -5 | 9 |
| 23 | St. Louis City | 4 | -1 | 4 | 4 | 0 | 4 | 8 | -1 | 8 |
| 24 | New England Revolution | 3 | -2 | 3 | 4 | -1 | 4 | 7 | -3 | 7 |
| 25 | Houston Dynamo | 4 | -4 | 3 | 4 | -2 | 3 | 8 | -6 | 6 |
| 26 | DC United | 5 | -1 | 5 | 3 | -8 | 1 | 8 | -9 | 6 |
| 27 | Sporting Kansas City | 5 | -3 | 4 | 3 | -3 | 0 | 8 | -6 | 4 |
| 28 | Toronto FC | 3 | -1 | 2 | 5 | -5 | 2 | 8 | -6 | 4 |
| 29 | Los Angeles Galaxy | 4 | -6 | 1 | 4 | -3 | 2 | 8 | -9 | 3 |
| 30 | CF Montréal | 1 | -1 | 0 | 7 | -8 | 2 | 8 | -9 | 2 |
Chicago Fire spelar sina hemmamatcher på Soldier Field i Chicago, Illinois som har en publikkapacitet på 62493 personer.
Chicago Fire mötte Inter Miami senast i MLS och matchen slutade oavgjort 0-0.
Chicago Fire möter FC Cincinnati härnäst på hemmaplan i MLS, med avspark 02:30 den 20/4.
Hemmaarena: Soldier Field
Kapacitet: 62493
Stad: Chicago, Illinois
Underlag: Gräs
